Cacoub P, Tazi Z, Koskas F, Gatel A, Piette J C, Kieffer E, Godeau P
Service de Médecine Interne, Hôpital de La Pitié-Salpêtrière, Paris.
Ann Med Interne (Paris). 1997;148(1):25-8.
Abdominal aortic aneurysms have usually been characterized as atheroslcerotic, but this view of their pathogenesis is a restricted one. As yet, no unified concept of pathogenesis has emerged, bat several factors appear to have an important role, including familial clustering, genetically determined and acquired biochemical alterations in the structural matrix of the aortic wall and bemodynamic mechanical factors. We review literature data concerning new pathogenic concepts of abdominal aortic aneurysms and particularly familial predisposition. Ultrasonographic screening is recommended in brothers (50 years) of patients with aneurysms of the abdominal aorta.
腹主动脉瘤通常被认为具有动脉粥样硬化特征，但这种关于其发病机制的观点较为局限。目前，尚未形成统一的发病机制概念，但有几个因素似乎起着重要作用，包括家族聚集性、主动脉壁结构基质中由基因决定和后天获得的生化改变以及血流动力学机械因素。我们回顾了有关腹主动脉瘤新发病机制概念，特别是家族易感性的文献数据。建议对腹主动脉瘤患者的兄弟（50岁）进行超声筛查。
