Panciera R J, Gatto N T, Crystal M A, Helman R G, Ely R W
College of Veterinary Medicine, Oklahoma State University, Stillwater 74078-2007, USA.
J Am Anim Hosp Assoc. 1997 May-Jun;33(3):221-5. doi: 10.5326/15473317-33-3-221.
Recognition of hepatozoonosis in four dogs that lived in Oklahoma their entire lifetimes documents expansion of the previously recognized endemic area of the disease. Salient clinical features are fever, marked neutrophilic leukocytosis, periosteal new bone proliferation, myalgia, weakness, muscle and generalized wasting, and lack of response to treatment. Transient, large-bowel diarrhea may be observed. Each of the four cases had signs compatible with chronic, persistent inflammatory disease that were poorly and ultimately nonresponsive to antimicrobial treatment. Diagnosis was confirmed in one case by recognition of Hepatozoon gamonts in peripheral blood leukocytes. Encysted forms of the organism were present in skeletal muscle and other tissues of each case.
对四只终生生活在俄克拉荷马州的犬类肝簇虫病的识别记录了该疾病先前已确认的地方病流行区域的扩大。显著的临床特征包括发热、明显的嗜中性白细胞增多、骨膜新骨增生、肌痛、虚弱、肌肉和全身消瘦以及对治疗无反应。可能会观察到短暂的大肠腹泻。这四个病例中的每一个都有与慢性持续性炎症性疾病相符的症状，对抗菌治疗反应不佳且最终无效。其中一例通过在外周血白细胞中识别出肝簇虫配子体而确诊。在每个病例的骨骼肌和其他组织中都存在该生物体的包囊形式。
