Männle C, Layer M, Vogt-Moykopf I, Becker H D, Zilow E P, Wiedemann K
Abt. für Anästhesiologie und Intensivmedizin, Thoraxklinik der LVA Baden, Heidelberg.
Anasthesiol Intensivmed Notfallmed Schmerzther. 1997 Jan;32(1):21-6. doi: 10.1055/s-2007-995002.
Between 1986 and 1996, 16 infants and children less than 11 years of age (m = 11, f = 5) underwent resections for acquired or congenital tracheobronchial stenoses. During this period, various techniques of total intravenous anaesthesia (TIVA) were employed (midazolam, fentanyl, pancuronium; propofol, fentanyl, pancuronium). During the phase of dividing the airways, high-frequency-jet ventilation (HFJV) into the trachea or the main bronchi by 8-12Fr catheter(s) was applied for 10-75 min with driving pressures between 0.3-1.8 bar, frequencies between 100-200/min, I:E ratio between 1:4-1:1, and FjetO2 1.0. Catheter position was controlled visually, gas exchange was monitored by pulse oximetry and blood gas analysis. There were two incidents of transient hypoxaemia (paO2 less than 60 mmHg), and 4 cases of hypercapnia (paCO2 more than 45 mmHg). No complications due to the HFJV-catheter technique, such as barotrauma or aspiration were seen. All children were kept postoperatively on a ventilator due to swelling of the airway anastomosis. In 5 children ventilator treatment exceeded 7 days, 3 children were discharged tracheostomised. These observations serve to confirm that HFJV is capable of maintaining gas exchange during tracheal resection in infants and children, if the following prerequisites are met: 1. Tracheobronchial pathology suitable for poststenotic placement of jet catheter. 2. No respiratory impairment by parenchymal pathology. 3. Monitoring by continuous visual control of respiratory mechanics, pulse oximetry and blood gas analysis. Cardiopulmonary bypass should be applied if airway pathology precludes safe placement of jet catheters, or in the presence of parenchymal respiratory failure.
1986年至1996年间,16名11岁以下的婴幼儿(男11例,女5例)因后天性或先天性气管支气管狭窄接受了切除术。在此期间,采用了多种全静脉麻醉(TIVA)技术(咪达唑仑、芬太尼、潘库溴铵;丙泊酚、芬太尼、潘库溴铵)。在气道分离阶段,通过8-12Fr导管向气管或主支气管进行高频喷射通气(HFJV)10-75分钟,驱动压力在0.3-1.8巴之间,频率在100-200次/分钟之间,吸呼比在1:4-1:1之间,喷射氧浓度为1.0。通过肉眼控制导管位置,通过脉搏血氧饱和度测定和血气分析监测气体交换。发生了2例短暂性低氧血症(动脉血氧分压低于60 mmHg)和4例高碳酸血症(动脉血二氧化碳分压高于45 mmHg)。未发现因HFJV导管技术导致的并发症,如气压伤或误吸。由于气道吻合口肿胀,所有儿童术后均需使用呼吸机。5名儿童的呼吸机治疗超过7天,3名儿童出院时带有气管造口。这些观察结果证实,如果满足以下前提条件,HFJV能够在婴幼儿气管切除术中维持气体交换:1. 气管支气管病变适合在狭窄部位后置喷射导管。2. 实质病变无呼吸功能损害。3. 通过持续肉眼观察呼吸力学、脉搏血氧饱和度测定和血气分析进行监测。如果气道病变妨碍喷射导管的安全置入,或存在实质呼吸衰竭,则应应用体外循环。