Downie W W, Lowe J R, Pickup M E
J Int Med Res. 1977;5 Suppl 2:20-5.
Phenylbutazone bioavailability from an enteric-coated formulation (Butacote) has been studied in normal volunteers following ingestion of a single 200 mg dose with water, aluminium hydroxide and magnesium trisilicate. No significant alteration in bioavailability of phenylbutazone from Butacote was noted in the presence of the antacids.
在正常志愿者中,研究了单次口服200毫克肠溶包衣制剂(Butacote),分别用水、氢氧化铝和三硅酸镁送服后的苯基布他松生物利用度。在使用抗酸剂的情况下,未观察到Butacote中苯基布他松的生物利用度有显著变化。