Caufriez A
Laboratory of Experimental Medicine, Université Libre de Bruxelles, Belgium.
Eur J Obstet Gynecol Reprod Biol. 1997 Feb;71(2):215-7. doi: 10.1016/s0301-2115(96)02638-3.
In puberty, the growth spurt and the appearance of secondary sex characteristics occur concomitantly with an increase of sex steroids, growth hormone (GH) and insulin-like growth factor I (IGF-I). A number of experiments indicate that sex steroids exert a stimulatory action on the somatotropic axis. This effect is due to an amplifying action of oestradiol (secreted by the ovaries or after testosterone aromatization) on the neuroendocrine regulation of pulsatile GH release.
在青春期，生长突增和第二性征的出现与性类固醇、生长激素（GH）和胰岛素样生长因子I（IGF-I）的增加同时发生。大量实验表明，性类固醇对生长激素轴发挥刺激作用。这种作用是由于雌二醇（由卵巢分泌或在睾酮芳香化后产生）对脉冲式GH释放的神经内分泌调节具有放大作用。
