Le Cann P, Tong M J, Werneke J, Coursaget P
Institute of Virology, School of Pharmacy, Tours, France.
Scand J Gastroenterol. 1997 Apr;32(4):387-9. doi: 10.3109/00365529709007689.
Viral hepatitis E (HIV) frequently causes epidemic outbreaks in many developing countries. It is also present in developed countries as imported cases. The role of hepatitis A virus as trigger for autoimmune chronic hepatitis has been demonstrated, and it has been suggested that this may also apply to HEV.
The presence of anti-HEV antibodies in serum samples from patients with autoimmune chronic active hepatitis (n = 52) and with primary biliary cirrhosis (n = 25) was investigated using an Abbott assay and a peptide-based test.
Anti-HEV antibodies were detected with the Abbott test in 13% (7 of 52) of the patients with autoimmune chronic active hepatitis, but not of these were positive in the synthetic peptide-based test.
These findings indicate the HEV is not associated with primary biliary cirrhosis but may be implicated in some cases of autoimmune chronic active hepatitis.
戊型肝炎病毒（HEV）在许多发展中国家经常引发疫情暴发。在发达国家也存在输入性病例。甲型肝炎病毒作为自身免疫性慢性肝炎触发因素的作用已得到证实，并且有人提出这可能也适用于戊型肝炎病毒。
使用雅培检测法和基于肽的检测方法，对自身免疫性慢性活动性肝炎患者（n = 52）和原发性胆汁性肝硬化患者（n = 25）的血清样本中抗戊型肝炎病毒抗体的存在情况进行了调查。
在自身免疫性慢性活动性肝炎患者中，13%（52例中的7例）通过雅培检测法检测到抗戊型肝炎病毒抗体，但在基于合成肽的检测中这些抗体均未呈阳性。
这些发现表明戊型肝炎病毒与原发性胆汁性肝硬化无关，但可能与某些自身免疫性慢性活动性肝炎病例有关。
