III型分泌系统：将细菌蛋白输送到真核细胞中的机器？
Type III secretion systems: machines to deliver bacterial proteins into eukaryotic cells?
作者信息
Lee C A
机构信息
Dept of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Microbiol. 1997 Apr;5(4):148-56. doi: 10.1016/S0966-842X(97)01029-9.
Type III secretion systems in certain bacterial pathogens are induced upon contact with host cells and directly deliver virulence proteins into the host cell cytosol. The increasing number of Gram-negative bacterial pathogens discovered to encode type III secretion systems raises interesting questions. Are type III systems generic machines that deliver virulence proteins into host cells? Is contact with host cells a common regulatory cue for type III systems?
某些细菌病原体中的III型分泌系统在与宿主细胞接触时被诱导，并直接将毒力蛋白输送到宿主细胞胞质溶胶中。越来越多被发现编码III型分泌系统的革兰氏阴性细菌病原体引发了有趣的问题。III型系统是将毒力蛋白输送到宿主细胞中的通用机器吗？与宿主细胞接触是III型系统常见的调节信号吗？
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