Wagner K L, Kaiser M, Korte W, Etzel F
Fortschr Med. 1977 Oct 20;95(39):2403-6.
During a period of 28 months 983 gynaecological patients had major abdominal or vaginal operations under Heparin prophylaxis. In no case thrombosis or pulmonary embolism occurred. 5 hemorrhages required surgical revision and temporary reduction of Heparin dose. Global tests for preoperative diagnosis of hemostasis and for postoperative control of Heparin effect are discussed. Possible reactive fibrinolysis under Heparin administration, its complications and control are mentioned. Peri- and postoperative prophylaxis of thrombo-embolism with Heparin in daily dosages up to 20,00 I.U. seems well suitable.
在28个月的时间里，983名妇科患者在肝素预防下接受了大型腹部或阴道手术。无一例发生血栓形成或肺栓塞。5例出血需要手术修正并暂时减少肝素剂量。讨论了用于术前止血诊断和术后肝素效果控制的全面检测。提及了肝素给药过程中可能出现的反应性纤维蛋白溶解、其并发症及控制方法。每日剂量高达20,000国际单位的肝素进行围手术期和术后血栓栓塞预防似乎非常合适。
