Ananthaswamy H N, Loughlin S M, Cox P, Evans R L, Ullrich S E, Kripke M L
Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Nat Med. 1997 May;3(5):510-4. doi: 10.1038/nm0597-510.
UV-induced mutations in the p53 tumor suppressor gene play an essential role in skin cancer development. We report here that such mutations can be detected in UV-irradiated mouse skin months before the gross appearance of skin tumors. Application of SPF-15 sunscreens to mouse skin before each UV irradiation nearly abolished the frequency of p53 mutations. These results indicate that p53 mutation is an early event in UV skin carcinogenesis and that inhibition of this event may serve as an early end point for assessing protective measures against skin cancer development.
紫外线诱导的p53肿瘤抑制基因中的突变在皮肤癌发展过程中起着至关重要的作用。我们在此报告，在皮肤肿瘤肉眼可见出现前数月，就能在紫外线照射的小鼠皮肤中检测到此类突变。每次紫外线照射前给小鼠皮肤涂抹防晒系数为15的防晒霜，几乎可消除p53突变的频率。这些结果表明，p53突变是紫外线皮肤致癌过程中的一个早期事件，抑制这一事件可作为评估预防皮肤癌发展保护措施的一个早期终点。
