Primary nonfunction of islet xenografts in rat recipients results from non-T-cell-mediated immune responses.

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作者信息

Deng S, Ketchum R J, Kucher T, Weber M, Naji A, Brayman K L

机构信息

Department of Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.

出版信息

Transplant Proc. 1997 May;29(3):1726-7. doi: 10.1016/s0041-1345(97)00032-8.

DOI:10.1016/s0041-1345(97)00032-8

PMID:9142249

Abstract

摘要

相似文献

Primary nonfunction of islet xenografts in rat recipients results from non-T-cell-mediated immune responses.

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Local immunologic factors determine the occurrence of primary nonfunction of islet xenografts.

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Six- to eight-month survival of discordant pig islet xenografts documented by differential species, insulin, and C-peptide in animals given short-term immunosuppression.在接受短期免疫抑制的动物中，通过不同物种、胰岛素和C肽记录不匹配猪胰岛异种移植的6至8个月存活率。

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Deoxyspergualin and rabbit antithymocyte globulin markedly prolong discordant pig pancreatic islet xenografts.

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A comparison of mice and rats as recipients for canine islet xenografts.

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Prevention of primary nonfunction of xenograft islets.

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NK cells, macrophages, and humoral immune responses are dominant in primary nonfunction of islet grafts in the dog-to-rat xenotransplant model.在犬到大鼠异种移植模型中，自然杀伤细胞、巨噬细胞和体液免疫反应在胰岛移植物原发性无功能中起主导作用。

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Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine genes abrogates primary nonfunction and prolongs graft survival.用免疫抑制细胞因子基因对犬胰岛异种移植物进行腺病毒转染可消除原发性无功能并延长移植物存活时间。

Transplant Proc. 1997 Feb-Mar;29(1-2):770. doi: 10.1016/s0041-1345(96)00477-0.

Survival of human islet xenografts irradiated with ultraviolet B in diabetic rats.

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Rat to mouse pancreas xenografts: comparison to islet xenografts.大鼠到小鼠胰腺异种移植：与胰岛异种移植的比较。

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Thrombomodulin improves early outcomes after intraportal islet transplantation.血栓调节蛋白可改善门静脉内胰岛移植后的早期疗效。

Am J Transplant. 2009 Jun;9(6):1308-16. doi: 10.1111/j.1600-6143.2009.02652.x. Epub 2009 May 20.

Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation.通过将代谢失调、炎症和免疫调节联系起来解决胰岛移植的难题。

Endocr Rev. 2008 Aug;29(5):603-30. doi: 10.1210/er.2008-0006. Epub 2008 Jul 29.

Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents.通过抗炎药物预防自身免疫性糖尿病NOD小鼠胰岛异种移植的原发性无功能。

Diabetologia. 2003 Aug;46(8):1115-23. doi: 10.1007/s00125-003-1154-0. Epub 2003 Jul 17.

Co-incubation of pig islet cells with spleen cells from non-obese diabetic mice causes decreased insulin release by non-T-cell- and T-cell-mediated mechanisms.将猪胰岛细胞与非肥胖糖尿病小鼠的脾细胞共同孵育，会通过非T细胞和T细胞介导的机制导致胰岛素释放减少。

Clin Exp Immunol. 2001 Jul;125(1):25-31. doi: 10.1046/j.1365-2249.2001.01572.x.

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