Huković S
Br J Pharmacol. 1997 Feb;120(4 Suppl):195-201; discussion 192-4. doi: 10.1111/j.1476-5381.1997.tb06799.x.
An isolated ductus deferens preparation together with the sympathetic hypogastric nerve of the guinea-pig is described. While the preparation showed no spontaneous contractions, nerve stimulation produced longitudinal contractions. The responses to successive periods of nerve stimulation remained constant for several hours. After noradrenaline had been added to the bath fluid for 30 min and then the fluid repeatedly changed to wash out the noradrenaline, the effect of nerve stimulation was greatly increased but declined in the course of 1 hr to the original height. Cocaine also increased the response to stimulation. Preparations made from guinea-pigs which had previously received reserpine responded to nerve stimulation with progressively diminishing contractions. In these circumstances, the administration of noradrenaline restored the response to nerve stimulation to that seen originally.
本文描述了一种分离出的豚鼠输精管标本,该标本连带交感神经腹下神经。该标本未表现出自发性收缩,但神经刺激可产生纵向收缩。对连续数小时的神经刺激的反应保持恒定。向浴液中加入去甲肾上腺素30分钟,然后反复更换浴液以冲洗掉去甲肾上腺素后,神经刺激的效果大大增强,但在1小时内降至原来的水平。可卡因也增强了对刺激的反应。由先前接受过利血平处理的豚鼠制备的标本,对神经刺激的反应是收缩逐渐减弱。在这些情况下,给予去甲肾上腺素可使对神经刺激的反应恢复到原来的水平。