豚鼠离体交感神经输精管标本的反应
Responses of the isolated sympathetic nerveductus deferens preparation of the guinea-pig.
作者信息
HUKOVIC S
出版信息
Br J Pharmacol Chemother. 1961 Apr;16(2):188-94. doi: 10.1111/j.1476-5381.1961.tb00312.x.
Abstract
An isolated ductus deferens preparation together with the sympathetic hypogastric nerve of the guinea-pig is described. While the preparation showed no spontaneous contractions, nerve stimulation produced longitudinal contractions. The responses to successive periods of nerve stimulation remained constant for several hours. After noradrenaline had been added to the bath fluid for 30 min and then the fluid repeatedly changed to wash out the noradrenaline, the effect of nerve stimulation was greatly increased but declined in the course of 1 hr to the original height. Cocaine also increased the response to stimulation. Preparations made from guinea-pigs which had previously received reserpine responded to nerve stimulation with progressively diminishing contractions. In these circumstances, the administration of noradrenaline restored the response to nerve stimulation to that seen originally.
摘要
本文描述了一种分离出的豚鼠输精管标本，该标本连同一部分交感神经下腹神经。该标本未表现出自发性收缩，但神经刺激可引起纵向收缩。对连续的神经刺激周期的反应在数小时内保持恒定。在浴液中加入去甲肾上腺素30分钟后，然后反复更换浴液以洗去去甲肾上腺素，神经刺激的效果大大增强，但在1小时内降至原来的水平。可卡因也增加了对刺激的反应。用先前接受过利血平处理的豚鼠制备的标本对神经刺激的反应是收缩逐渐减弱。在这些情况下，给予去甲肾上腺素可使对神经刺激的反应恢复到原来的水平。
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