Baynes R E, Craigmill A L, Riviere J E
Food Animal Residue Avoidance Databank, Cutaneous Pharmacology and Toxicology Center, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
J Am Vet Med Assoc. 1997 May 1;210(9):1288-9.
Deriving adequate withdrawal intervals for extralabel use of veterinary topical products is difficult because there are limited published data, and data for approved drugs and pesticides are usually proprietary. Where possible, approved products and doses labeled for the specific indication at hand should be used and label withdrawal times should be adhered to. When determining whether topical application of these chemicals may violate tolerance levels in meat and milk, the veterinarian often is limited to empirical data. In the decision-making process, factors, such as type of drug and pesticide formulations used, method of topical application, presence of hair or wool, environmental conditions, and animal species treated, should be considered. In many cases a conservative estimate for the slaughter withdrawal interval can be derived, despite the data gaps. Such recommendations should not be used for routine extralabel use, but are meant to apply to situations in which the drug or pesticide has been used, and human food safety concerns must be addressed.
确定兽用局部用产品超说明书使用的适当停药期很困难，因为公开数据有限，而且获批药物和农药的数据通常是保密的。只要有可能，就应使用针对手头特定适应症获批的产品和剂量，并遵守标签上的停药时间。在确定这些化学品的局部应用是否可能违反肉类和牛奶中的耐受水平时，兽医往往只能依据经验数据。在决策过程中，应考虑所用药物和农药制剂的类型、局部应用方法、毛发或羊毛的存在情况、环境条件以及所治疗的动物种类等因素。尽管存在数据缺口，但在许多情况下仍可得出屠宰停药期的保守估计值。此类建议不应被用于常规的超说明书使用，而是适用于已使用药物或农药且必须解决人类食品安全问题的情况。
