Schnegg A, Kirchgessner M
Int J Vitam Nutr Res. 1977;47(3):274-6.
In previous studies on the essentiality of nickel, a reduced iron absorption causing anemia was observed. Since Ni deficiency also affects Zn metabolism, the different phosphatase activities were determined. Ni deficiency, however, resulted in an increased activity of the alkaline phosphatase in liver. On the other hand, the activity of the alkaline phosphatase was deduced by 59% during Fe deficiency. Similarly, the alkaline and acid phosphatases in serum were reduced during Fe deficiency. Consequently, determination of the activity of the alkaline phosphatase in serum, besides that of various liver enzymes, is suited well to differentiate between Fe and Ni deficiency.
在以往关于镍必需性的研究中，观察到铁吸收减少会导致贫血。由于镍缺乏也会影响锌代谢，因此测定了不同的磷酸酶活性。然而，镍缺乏导致肝脏中碱性磷酸酶的活性增加。另一方面，缺铁时碱性磷酸酶的活性降低了59%。同样，缺铁时血清中的碱性和酸性磷酸酶也会降低。因此，除了测定各种肝脏酶的活性外，测定血清中碱性磷酸酶的活性也非常适合区分缺铁和缺镍。
