（RS）-2-氯-5-羟基苯甘氨酸（CHPG）可激活在CHO细胞中表达的代谢型谷氨酸受体5（mGlu5），但不激活代谢型谷氨酸受体1（mGlu1），并增强海马体中的N-甲基-D-天冬氨酸（NMDA）反应。
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
作者信息
Doherty A J, Palmer M J, Henley J M, Collingridge G L, Jane D E
机构信息
Department of Anatomy, School of Medical Sciences, University of Bristol, UK.
出版信息
Neuropharmacology. 1997 Feb;36(2):265-7. doi: 10.1016/s0028-3908(97)00001-4.
A new phenylglycine derivative, (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), has been synthesized and shown to selectively activate mGlu5a receptors, compared to mGlu1 alpha receptors, when expressed in CHO cells. This selective mGlu5 receptor agonist also potentiates NMDA-induced depolarizations in rat hippocampal slices. CHPG may be a useful tool for studying the role of mGlu5 receptors in the central nervous system.
一种新的苯甘氨酸衍生物，（RS）-2-氯-5-羟基苯甘氨酸（CHPG），已被合成，并且当在CHO细胞中表达时，与mGlu1α受体相比，它能选择性地激活mGlu5a受体。这种选择性的mGlu5受体激动剂还能增强大鼠海马切片中NMDA诱导的去极化。CHPG可能是研究mGlu5受体在中枢神经系统中作用的有用工具。
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