Katzberg R W, Morris T W, Burgener F A, Kamm D E, Fischer H W
Invest Radiol. 1977 Sep-Oct;12(5):381-8. doi: 10.1097/00004424-197709000-00002.
Selective renal artery catheterization and renal angiography are commonly performed diagnostic procedures; however, the effects of these procedures on renal blood flow (RBF) and renin release have only been partially described. A biphasic RBF response has been well documented furing selective angiography in dogs. The renal autoregulatory mechanisms governing the responses are uncertain. The renin-angiotensin system and the major parameters of contrast media, hypertonicity and viscosity, have been suggested as important factors. In the canine model, we examined the acute changes in renal venous renin activity along with the renal hemodynamic effects of hypertonicity and viscosity. Our results do not support a primary effect mediated by the renin-angiotensin system. Hypertonicity and the contrast medium per se are significant in active and passive autoregulatory responses at the smooth muscle cellular level.
选择性肾动脉插管和肾血管造影是常用的诊断程序；然而，这些程序对肾血流量（RBF）和肾素释放的影响仅得到部分描述。在犬类选择性血管造影过程中，肾血流量的双相反应已有充分记录。控制这些反应的肾自动调节机制尚不确定。肾素-血管紧张素系统以及造影剂的主要参数（高渗性和粘度）被认为是重要因素。在犬类模型中，我们研究了肾静脉肾素活性的急性变化以及高渗性和粘度对肾血流动力学的影响。我们的结果不支持肾素-血管紧张素系统介导的主要作用。在平滑肌细胞水平，高渗性和造影剂本身在主动和被动自动调节反应中具有重要意义。
