Suzuki T, Suganuma T, Shimizu R, Aoki M, Hanano M
Department of Pharmaceutical Science, College of Pharmacy, Nihon University, Chiba, Japan.
Biol Pharm Bull. 1997 Apr;20(4):438-42. doi: 10.1248/bpb.20.438.
The relationship between the pharmacokinetic properties and the analgesic effect of indomethacin (IDM) was evaluated on a carrageenin-induced inflammation model in the rat. Rats were administered the drug in one of two ways: intravenous (i.v.) IDM bolus or i.v. IDM infusion. The analgesic activity was measured by Randall-Selitto test. No correlation was observed between the analgesic effect and the plasma IDM concentration after i.v. bolus administration of IDM. However, in the case of infusion, IDM produced a dose-dependent analgesic effect. In this paper, we demonstrated that the plasma concentration of IDM maintained by i.v. infusion had a prolonged analgesic effect on the carrageenin-induced inflammation model.
在大鼠角叉菜胶诱导的炎症模型上评估了吲哚美辛（IDM）的药代动力学性质与镇痛效果之间的关系。大鼠通过以下两种方式之一给药：静脉注射（i.v.）IDM推注或静脉输注IDM。通过Randall-Selitto试验测量镇痛活性。静脉推注IDM后，未观察到镇痛效果与血浆IDM浓度之间存在相关性。然而，在输注的情况下，IDM产生剂量依赖性镇痛作用。在本文中，我们证明了静脉输注维持的IDM血浆浓度对角叉菜胶诱导的炎症模型具有延长的镇痛作用。
