Middelton L A, Peters K F, Helmbold E A
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Cancer Nurs. 1997 Apr;20(2):129-47; quiz 148-51. doi: 10.1097/00002820-199704000-00008.
The information gained from the Human Genome Project and related genetic research will undoubtedly create significant changes in health care practice. It is becoming increasing clear that nurses in all areas of clinical practice will require a fundamental understanding of basic genetics. This self-learning module provides the oncology nurse with an overview of basic genetic concepts including inheritance patterns of single gene conditions, pedigree construction, chromosome aberrations, and the multifactorial basis underlying many common diseases of adulthood. Normal gene structure and function will be introduced and the biochemistry of genetic errors will be described.
从人类基因组计划及相关基因研究中获得的信息无疑将给医疗实践带来重大变革。越来越明显的是,临床实践各个领域的护士都需要对基础遗传学有基本的了解。这个自学模块为肿瘤学护士提供了基础遗传学概念的概述,包括单基因疾病的遗传模式、系谱构建、染色体畸变以及许多常见成人疾病背后的多因素基础。将介绍正常基因的结构和功能,并描述基因错误的生物化学机制。