内生合成的泰乐菌素在弗氏链霉菌中诱导ermSF的关键作用。
Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae.
作者信息
Memili E, Weisblum B
机构信息
Pharmacology Department, University of Wisconsin Medical School, Madison 53706, USA.
出版信息
Antimicrob Agents Chemother. 1997 May;41(5):1203-5. doi: 10.1128/AAC.41.5.1203.
Abstract
We compared ermSF induction in wild-type Streptomyces fradiae NRRL B-2702 and that in GS-14, a tylA mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays an obligatory role in ermSF induction and (ii) tylosin, or a biosynthetic intermediate beyond tylactone, has an "autocrine" function that induces ErmSF synthesis, thereby enabling S. fradiae to resist higher levels of tylosin.
摘要
我们比较了野生型弗氏链霉菌NRRL B - 2702和GS - 14（一种无法合成泰乐菌素的tylA突变体）中ermSF的诱导情况。我们的研究结果表明：（i）内源性合成的泰乐菌素在ermSF诱导中起关键作用；（ii）泰乐菌素或泰乐内酯以外的生物合成中间体具有“自分泌”功能，可诱导ErmSF合成，从而使弗氏链霉菌能够抵抗更高水平的泰乐菌素。
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