Macdonald R L, Greenfield L J
Department of Neurology, University of Michigan Medical Center, Ann Arbor, USA.
Curr Opin Neurol. 1997 Apr;10(2):121-8. doi: 10.1097/00019052-199704000-00009.
Many new antiepileptic drugs have been developed to treat seizure disorders. The established antiepileptic drugs reduce neuronal excitability by promoting sodium channel inactivation, inhibiting T-type calcium channels, or enhancing gamma-aminobutyric acid type A receptor-mediated inhibition. Several of the newer agents employ similar mechanisms, whereas others may enhance gamma-aminobutyric acid-ergic inhibitory systems or inhibit glutamatergic excitatory neurotransmission, and may be neuroprotective or antiepileptogenic.
许多新型抗癫痫药物已被研发用于治疗癫痫发作性疾病。已有的抗癫痫药物通过促进钠通道失活、抑制T型钙通道或增强γ-氨基丁酸A型受体介导的抑制作用来降低神经元兴奋性。几种较新的药物采用类似机制，而其他药物可能增强γ-氨基丁酸能抑制系统或抑制谷氨酸能兴奋性神经传递，并且可能具有神经保护或抗癫痫发生作用。
