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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Gen Pharmacol. 1997 Apr;28(4):503-7. doi: 10.1016/s0306-3623(96)00279-0.

Mn2+ (5 mM) evoked the contraction of ileal longitudinal muscle in a Ca(2+)-free, high-K+ (60 mM) medium. Metabolic inhibitors, such as iodoacetic acid or glucose removal, reduced the contraction by Mn2+ in the Ca(2+)-free, high-K+ medium, suggesting that the contraction by Mn2+ depends on energy metabolism. 2. By the abrupt decrease in length of the ileum during contraction 3 hr after the addition of 5 mM Mn2+ in Ca(2+)-free, high-K+ medium, a rapid decrease in tension was seen, and redevelopment of tension followed, which is indicative of an active state. 3. In the late phase, 5 hr after the Mn(2+)-induced contraction, a similar decrease in the length also caused a rapid decrease in tension, without however, a redevelopment of tension. This probably indicates that the myofilaments in this phase transferred to a state of static interaction.

在无钙、高钾（60 mM）培养基中，Mn2+（5 mM）可诱发回肠纵肌收缩。代谢抑制剂，如碘乙酸或去除葡萄糖，可降低无钙、高钾培养基中Mn2+引起的收缩，这表明Mn2+引起的收缩依赖于能量代谢。2. 在无钙、高钾培养基中加入5 mM Mn2+ 3小时后，回肠在收缩过程中长度突然缩短，张力迅速下降，随后张力重新恢复，这表明处于活跃状态。3. 在后期，即Mn2+诱导收缩5小时后，类似的长度缩短也会导致张力迅速下降，但张力不会重新恢复。这可能表明此阶段的肌丝已转变为静态相互作用状态。

Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.

Gen Pharmacol. 1997 Apr;28(4):503-7. doi: 10.1016/s0306-3623(96)00279-0.

Mn2+ (5 mM) evoked the contraction of ileal longitudinal muscle in a Ca(2+)-free, high-K+ (60 mM) medium. Metabolic inhibitors, such as iodoacetic acid or glucose removal, reduced the contraction by Mn2+ in the Ca(2+)-free, high-K+ medium, suggesting that the contraction by Mn2+ depends on energy metabolism. 2. By the abrupt decrease in length of the ileum during contraction 3 hr after the addition of 5 mM Mn2+ in Ca(2+)-free, high-K+ medium, a rapid decrease in tension was seen, and redevelopment of tension followed, which is indicative of an active state. 3. In the late phase, 5 hr after the Mn(2+)-induced contraction, a similar decrease in the length also caused a rapid decrease in tension, without however, a redevelopment of tension. This probably indicates that the myofilaments in this phase transferred to a state of static interaction.

在无钙、高钾（60 mM）培养基中，Mn2+（5 mM）可诱发回肠纵肌收缩。代谢抑制剂，如碘乙酸或去除葡萄糖，可降低无钙、高钾培养基中Mn2+引起的收缩，这表明Mn2+引起的收缩依赖于能量代谢。2. 在无钙、高钾培养基中加入5 mM Mn2+ 3小时后，回肠在收缩过程中长度突然缩短，张力迅速下降，随后张力重新恢复，这表明处于活跃状态。3. 在后期，即Mn2+诱导收缩5小时后，类似的长度缩短也会导致张力迅速下降，但张力不会重新恢复。这可能表明此阶段的肌丝已转变为静态相互作用状态。