Botsis D, Kassanos D, Kalogirou D, Karakitsos P, Liapis A, Antoniou G
2nd Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
Maturitas. 1997 Apr;26(3):203-9. doi: 10.1016/s0378-5122(96)01097-3.
To evaluate whether transvaginal color Doppler and CA125 are valid in differentiating malignant from benign postmenopausal ovarian masses.
Sixty-two women with ovarian masses were studied with transvaginal color Doppler ultrasound before surgery. Serum CA125 levels were also measured. Resistance index (RI) and pulsatility index (PI) were calculated from the waveforms generated from blood flow within the ovary.
Benign tumors had a significantly higher pulsatility index (mean 1.23 +/- 1.02; range 0.65-2.99) and resistive index (mean 0.78 +/- 0.22; range 0.5-1.1) than did malignant tumors. However some overlap in individual values for benign and malignant lesions was found. RI and PI sensitivity were significantly higher than those with CA125 (P < 0.05). Blood flow was detectable by color Doppler imaging in 95% of cases with malignant masses.
Doppler sonographic evaluation of resistance and pulsatility indexes in the vessels of ovarian masses together with CA125 increased the sensitivity of prediction of malignancy for pelvic masses, but further work is needed before the validity of these factors is proved.
评估经阴道彩色多普勒和CA125在鉴别绝经后卵巢肿块的良恶性方面是否有效。
62例患有卵巢肿块的女性在手术前接受经阴道彩色多普勒超声检查。同时测量血清CA125水平。根据卵巢内血流产生的波形计算阻力指数（RI）和搏动指数（PI）。
良性肿瘤的搏动指数（平均1.23±1.02；范围0.65 - 2.99）和阻力指数（平均0.78±0.22；范围0.5 - 1.1）显著高于恶性肿瘤。然而，发现良性和恶性病变的个体值存在一些重叠。RI和PI的敏感性显著高于CA125（P < 0.05）。95%的恶性肿块病例通过彩色多普勒成像可检测到血流。
对卵巢肿块血管的阻力和搏动指数进行多普勒超声评估并结合CA125可提高盆腔肿块恶性预测的敏感性，但在证实这些因素的有效性之前还需要进一步研究。
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