Imamura K, Richter H, Fischer H, Lennerstrand G, Franzén O, Rydberg A, Andersson J, Schneider H, Onoe H, Watanabe Y, Långström B
Subfemtomole Biorecognition Project, Japan Science and Technology Corporation, Osaka, Japan.
Neurosci Lett. 1997 Apr 11;225(3):173-6. doi: 10.1016/s0304-3940(97)00211-5.
In order to examine the relationship between reduced visual acuity in human strabismic amblyopia and the cortical activation pattern, we studied, by use of positron emission tomography (PET) and the H2(15)O bolus technique, changes in the regional cerebral blood flow (rCBF) induced by monocular visual stimulation of 8 individuals with this disorder. Individual amblyopic thresholds for monocular detection of the checkerboard pattern were employed as stimuli for both eyes during PET scans. Statistical analysis of subtracted images showed significant increases in rCBF (P < 0.05) by the stimulation of the sound eye localized bilaterally to Brodmann's areas (BAs) 17-19. The cortical response evoked by the amblyopic eye was significantly reduced (P < 0.05) in the ipsilateral BAs 18, 19. These results suggest that the reduction in contrast sensitivity (pattern vision) in amblyopia is coupled with deactivation in identifiable regions of occipital visual areas, including ipsilateral BAs 18,19.
为了研究人类斜视性弱视患者视力下降与皮质激活模式之间的关系，我们利用正电子发射断层扫描（PET）和H2(15)O团注技术，研究了8例该疾病患者单眼视觉刺激引起的局部脑血流量（rCBF）变化。在PET扫描期间，将个体单眼检测棋盘格图案的弱视阈值用作双眼的刺激。对相减图像的统计分析表明，健眼刺激使双侧Brodmann区（BA）17 - 19的rCBF显著增加（P < 0.05）。弱视眼诱发的皮质反应在同侧BA 18、19中显著降低（P < 0.05）。这些结果表明，弱视患者对比敏感度（模式视觉）的降低与枕叶视觉区域可识别区域的失活有关，包括同侧BA 18、19。
