Roszkowski M, Barszcz S, Dramińska D, Kościesza A, Grajkowska W, Gardas-Skowrońska A
Oddziału Neurochirurgii Dzieciecej IPCZD w Warszawie.
Neurol Neurochir Pol. 1996 Sep-Oct;30(5):797-810.
A series of 81 children with craniopharyngiomas is presented. All patients were operated on between 1981 and 1992. According to the applied treatment the presented group was divided into three distinct categories. 28 patients underwent what was considered by the surgeon to be total excision of their tumour, 27 bad partial excision, in the rest 26 children partial excision of the tumour was followed by local rtgtherapy. The impact on the outcome, the statistically estimated probability of event-free survival, following different type of applied treatment was the main aim of this study. The 5- and 10-year actuarial recurrence free survival rate were 78% and 52% respectively, for total removal group, versus 46% and 28% for partial removal, and 49% and 18% for partial removal followed by megavoltage irradiation. The study show a statistically significant advantage for radial surgical removal of childhood craniopharyngioma in event free survival. It is emphasized that total resection using modern diagnostic and surgical methods is the mainstay for childhood carniopharyngioma. Nearly 87% of pediatric craniopharyngiomas can be totally resected.
本文报告了一组81例颅咽管瘤患儿。所有患者均于1981年至1992年间接受手术治疗。根据所采用的治疗方法，该组患者被分为三个不同类别。28例患者接受了外科医生认为的肿瘤全切手术，27例接受了部分切除手术，其余26例患儿在肿瘤部分切除后接受了局部放疗。本研究的主要目的是探讨不同治疗方式对预后的影响，即统计学上估计的无事件生存率。全切组的5年和10年精算无复发生存率分别为78%和52%，部分切除组为46%和28%，部分切除后接受兆伏级放疗组为49%和18%。研究表明，在无事件生存方面，根治性手术切除儿童颅咽管瘤具有统计学上的显著优势。强调采用现代诊断和手术方法进行全切是儿童颅咽管瘤治疗的主要手段。近87%的儿童颅咽管瘤可以实现全切。
