Helmstaedter C, Kemper B, Elger C E
University Clinic of Epileptology, Bonn Germany.
Neuropsychologia. 1996 May;34(5):399-406. doi: 10.1016/0028-3932(95)00121-2.
While most neuropsychological studies in focal epilepsies are concerned with temporal lobe epilepsy (TLE), only few investigations aim cognitive functioning in unresected patients with frontal lobe epilepsy (FLE). Following functional models arising from lesional studies, we evaluated patients with TLE (21 left, 17 right) and FLE (6 left, 17 right) with respect to attention and speed, motor coordination, verbal/nonverbal fluency, concept formation, response inhibition, anticipatory behavior and memory span. The following results were obtained. When compared to TLE, FLE was associated with significantly poorer results in almost all tests, fluency tests being the exception. No group differences were found with respect to the lateralization of the epileptic focus or the presence or absence of cerebral lesions. Factor analysis of the tests indicated that different subfunctions (speed, STM, motor coordination, response maintenance and inhibition) were assessed. A particular cognitive pattern of impaired motor coordination or response inhibition appeared to be characteristic for patients with FLE.
虽然大多数关于局灶性癫痫的神经心理学研究都关注颞叶癫痫（TLE），但只有少数研究针对未接受手术的额叶癫痫（FLE）患者的认知功能。根据病灶研究得出的功能模型，我们评估了TLE患者（左侧21例，右侧17例）和FLE患者（左侧6例，右侧17例）在注意力和速度、运动协调、言语/非言语流畅性、概念形成、反应抑制、预期行为和记忆广度方面的情况。得到了以下结果。与TLE相比，FLE在几乎所有测试中的结果都明显更差，流畅性测试除外。在癫痫病灶的定位或是否存在脑损伤方面未发现组间差异。对测试进行的因子分析表明评估了不同的子功能（速度、短时记忆、运动协调、反应维持和抑制）。运动协调或反应抑制受损的特定认知模式似乎是FLE患者的特征。
