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如今肺切除术的风险有多大?——开胸手术围手术期的发病率和死亡率

[How risky is lung resection today?--perioperative morbidity and mortality in open thorax surgery].

作者信息

Gross T, Roth C, Zwimpfer M, Metzger U

机构信息

Chirurgische Klinik, Stadtspital Triemli Zürich.

出版信息

Schweiz Med Wochenschr. 1997 Mar 15;127(11):430-5.

PMID:9148397
Abstract

We retrospectively analyzed hospital morbidity and mortality following primary open lung surgery from August 1990 to December 1994 in 187 consecutive patients. 180 pulmonary resections and 7 exploratory thoracotomies were performed in 141 men and 46 women, with mean age 60.4 +/- 11.9 years. 142 patients were aged < 70 years (median 58.5), and 45 (25%) > 70 years (median 73). Tumor stage as well as preoperative ASA classification and FEV1 were similar in these age groups. No difference could be found in hospital morbidity of elderly compared to younger patients (> or = 70 years: 40%; < 70 years: 40.8%), but 30-day mortality was higher in elderly (8.9% versus 2.8% in younger subjects). Elderly patients who died postoperatively presented a higher preoperative risk (ASA 2.75) compared to nonfatal cases in the same age group (ASA 2.18). Morbidity and mortality increased with the extent of surgery; the 30-day mortality was nil in the group of wedge and segmental resections (0/23), 1.9% in lobectomies (2/106) and 7.8% in pneumonectomies (4/51). Our results in general match those of comparable centers in Switzerland and the international literature. Since the overall complication rate was not increased compared to younger patients, we assume that polymorbidity of single cases was the cause of higher mortality after extended open lung surgery in septuagenarians and octogenarians. In consequence, the scope of surgery should be reduced as far as possible. In addition, the perioperative risk for the senescent patient can be improved by identification of high risk cases. With this attitude we take the view that lung resection can honestly be recommended to the elderly also.

摘要

我们回顾性分析了1990年8月至1994年12月期间连续187例患者接受初次开放性肺手术后的医院发病率和死亡率。对141名男性和46名女性进行了180例肺切除术和7例 exploratory thoracotomies,平均年龄为60.4±11.9岁。142例患者年龄<70岁(中位数58.5岁),45例(25%)年龄>70岁(中位数73岁)。这些年龄组的肿瘤分期、术前ASA分级和FEV1相似。与年轻患者相比,老年患者的医院发病率无差异(≥70岁:40%;<70岁:40.8%),但老年患者的30天死亡率较高(8.9%对年轻患者的2.8%)。与同年龄组的非致命病例相比,术后死亡的老年患者术前风险更高(ASA 2.75)。发病率和死亡率随手术范围的扩大而增加;楔形和节段性切除组的30天死亡率为零(0/23),肺叶切除组为1.9%(2/106),全肺切除组为7.8%(4/51)。我们的结果总体上与瑞士同类中心及国际文献的结果相符。由于与年轻患者相比总体并发症发生率并未增加,我们认为单例患者的多种疾病是七十岁及八十岁以上患者扩大开放性肺手术后死亡率较高的原因。因此,应尽可能缩小手术范围。此外,通过识别高危病例可以改善老年患者的围手术期风险。基于这种态度,我们认为肺切除术也可以诚实地推荐给老年人。 (注:“exploratory thoracotomies”此处未准确对应中文医学术语,可根据具体情况进一步明确其准确释义,这里暂保留英文表述。)

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