Silber S H
Department of Emergency Medicine, New York Methodist Hospital, Brooklyn, NY 11215, USA.
Am J Emerg Med. 1997 May;15(3):263-7. doi: 10.1016/s0735-6757(97)90010-3.
A questionnaire entitled "Survey of Protocols for Rapid Sequence Intubation in Previously Healthy Adults with Elevated Intracranial Pressure" was distributed to the program directors of all 100 emergency medicine residency programs listed in the Directory of Graduate Medical Education Programs in February 1995. The medical literature on rapid sequence intubation in patients with suspected intracranial pressure elevations was reviewed. The findings of the review were compared with the survey responses. Sixty-seven program directors responded to the survey. Sixty-five programs performed rapid sequence intubation in their institution. Five programs performed 0 to 10 procedures annually. Six performed 10 to 30 annually, 19 performed 30 to 50, 17 performed 50 to 100, and 18 performed more than 100. Succinylcholine and vecuronium were the most frequently used neuromuscular blockers. Midazolam and thiopental were the most frequently used sedative induction agents. Most programs use a defasciculating agent prior to succinylcholine administration. The majority of programs do not use a priming agent before the use of a nondepolarizing neuromuscular blocking agent. Intravenous lidocaine was routinely administered prior to neuromuscular blockade. Fentanyl was the most frequently used other pretreatment medication. Rapid sequence intubation is used to facilitate definitive, emergent airway management in patients with suspected intracranial pressure elevations in almost all of the emergency medicine residency programs that responded to the survey. Most of these programs follow the guidelines recommended in the medical literature. The majority of these guidelines, however, are based on statistical data performed in the laboratory or nonemergency environments. Further clinical studies in an emergency medicine environment must be performed to determine the optimal drug regimen for rapid sequence intubation in patients with elevated intracranial pressure.
一份名为《既往健康的颅内压升高成人快速顺序诱导插管方案调查》的问卷,于1995年2月分发给了《研究生医学教育项目目录》中列出的所有100个急诊医学住院医师培训项目的项目主任。对有关疑似颅内压升高患者快速顺序诱导插管的医学文献进行了综述。将综述结果与调查回复进行了比较。67位项目主任回复了调查。65个项目在其机构中进行快速顺序诱导插管。5个项目每年进行0至10例手术。6个项目每年进行10至30例,19个项目每年进行30至50例,17个项目每年进行50至100例,18个项目每年进行超过100例。琥珀胆碱和维库溴铵是最常用的神经肌肉阻滞剂。咪达唑仑和硫喷妥钠是最常用的镇静诱导剂。大多数项目在给予琥珀胆碱之前使用去极化阻滞剂。大多数项目在使用非去极化神经肌肉阻滞剂之前不使用预充剂。在神经肌肉阻滞之前常规给予静脉利多卡因。芬太尼是最常用的其他预处理药物。在几乎所有回复调查的急诊医学住院医师培训项目中,快速顺序诱导插管用于促进对疑似颅内压升高患者进行确定性的紧急气道管理。这些项目中的大多数遵循医学文献中推荐的指南。然而,这些指南中的大多数是基于在实验室或非紧急环境中进行的统计数据。必须在急诊医学环境中进行进一步的临床研究,以确定颅内压升高患者快速顺序诱导插管的最佳药物方案。