Fogel K, Szeiffert G, Görcs T J, Kausz M, Köves K
Department of Humanmorphology and Developmental Biology, Semmelweis University Medical School, Budapest, Hungary.
Peptides. 1997;18(2):263-7. doi: 10.1016/s0196-9781(96)00288-4.
This is the first report showing VIP fibers in the optic chiasm and the optic nerves of intact rats. These fibers form a fan-shaped dorso-medial bundle in the optic nerves. After colchicine injection into the vitreous body VIP fibers could be followed farther in the optic nerve toward the eye when compared to intact rats. After removal of eyes (enucleation) the VIP fiber-bundle became more prominent and VIP immunoreactive perikarya appeared in the supraoptic and para ventricular nuclei. When five-nine months after the enucleation Phaseolus vulgaris leucoagglutinin was administered to the paraventricular or supraoptic area, the anterogradely transported tracer was demonstrated in the optic nerve. These observations suggest the existence of a hypothalamic projection to the eye, which is, at least in part, VIP immunoreactive.
这是首份显示在完整大鼠的视交叉和视神经中有血管活性肠肽（VIP）纤维的报告。这些纤维在视神经中形成一个扇形的背内侧束。与完整大鼠相比，向玻璃体注射秋水仙碱后，VIP纤维在视神经中可向眼的方向延伸得更远。摘除眼球（眼球摘除术）后，VIP纤维束变得更加明显，并且在视上核和室旁核中出现了VIP免疫反应阳性的核周体。在眼球摘除术后五至九个月，当将菜豆白细胞凝集素注入室旁或视上区域时，在视神经中可显示出顺行运输的示踪剂。这些观察结果表明存在从下丘脑到眼的投射，至少部分是VIP免疫反应阳性的。
