一种用于人类免疫缺陷病毒的活病毒“自杀”疫苗。

A live-virus "suicide" vaccine for human immunodeficiency virus.

作者信息

Kestler H W, Chakrabarti B K

机构信息

Department of Molecular Biology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA.

出版信息

Cleve Clin J Med. 1997 May;64(5):269-74. doi: 10.3949/ccjm.64.5.269.

DOI:10.3949/ccjm.64.5.269

PMID:9149478

Abstract

A vaccine that uses a live, attenuated human immunodeficiency virus (HIV) may offer the best hope of a vaccine against acquired immunodeficiency syndrome (AIDS). A recent improvement should increase the safety of the live-virus approach: a "suicide gene" inserted into the viral RNA, which causes infected cells to die when treated with ganciclovir. We envision using this strategy not only to prevent AIDS, but also to treat it.

摘要

一种使用减毒活人类免疫缺陷病毒（HIV）的疫苗可能为预防获得性免疫缺陷综合征（AIDS）带来最大希望。最近的一项改进应能提高活病毒方法的安全性：将一个“自杀基因”插入病毒RNA中，当用更昔洛韦处理时，该基因会导致受感染细胞死亡。我们设想不仅使用这种策略来预防艾滋病，还使用它来治疗艾滋病。