Shimamoto K, Ando T, Nakao T, Watarai I, Miyahara M
J Clin Endocrinol Metab. 1977 Oct;45(4):818-20. doi: 10.1210/jcem-45-4-818.
In eight patients undergoing chronic hemodialysis, ultrafiltration was performed for 1 h in each patient. The concentration of urea nitrogen, creatinine, ADH, cortisol, GH, prolactin and TSH was measured in plasma and the filtering solution, and the permeability of each substance was determined. The plasma concentration of ADH coincided with that of the filtering solution, and no significant difference was noted between the permeability of creating and ADH. In contrast, cortisol, GH, prolactin and TSH were not detected in the filtering solution. Chromatographic study showed that ADH in the filtering solution coincided with synthetic ADH. From a comparison of the permeability with the molecular weight, it was suggested that ADH in the blood exists in free form without binding with plasma proteins or neurophysin.
对8例接受慢性血液透析的患者，每位患者进行1小时的超滤。测定血浆和滤出液中尿素氮、肌酐、抗利尿激素（ADH）、皮质醇、生长激素（GH）、催乳素和促甲状腺激素（TSH）的浓度，并确定每种物质的通透性。ADH的血浆浓度与滤出液中的浓度一致，肌酐和ADH的通透性之间未发现显著差异。相比之下，滤出液中未检测到皮质醇、GH、催乳素和TSH。色谱研究表明，滤出液中的ADH与合成ADH一致。通过将通透性与分子量进行比较，提示血液中的ADH以游离形式存在，不与血浆蛋白或神经垂体素结合。
