Brody I
J Cutan Pathol. 1977;4(2):68-79. doi: 10.1111/j.1600-0560.1977.tb00891.x.
This is a light- and electron-microscopic study of excoriated, recalcitrant psoriatic lesions in ambulatory patients undergoing topical treatment. During regeneration of a stratum corneum without scales, in areas showing excoriations bounded by a non-cornified epidermis, horny cell layers, designated I and II, are formed. In areas in which excoriations are delimited by an epidermis with a retained stratum corneum, the latter is composed of a horny cell layer I and/or II or III. The horny cell layers differ, as shown by light- and electron-microscopy. In the less fresh excoriations, a homogeneous substance, which includes fibrin deposits, is observed. This substance is also seen frequently in the stratum corneum. In the less fresh excoriations and in the stratum corneum there are numerous polymorphonuclear leukocytes. In these locations, however, they are only found simultaneously with the homogeneous substance containing fibrin deposits. Polymorphonuclear leukocytes are also seen in the dermal papillae and in the non-cornified epidermis, particularly in the macroscopically "old" excoriations. The changes observed in these recalcitrant lesions have been interpreted as secondary and are believed to be expressions of a non-specific reaction to the mechanical damage to which the ambulatory patients have constantly exposed the lesions. They are not interpreted as changes in the psoriatic condition per se.
这是一项对接受局部治疗的门诊患者的剥脱性、顽固性银屑病皮损进行光镜和电镜研究。在无鳞屑的角质层再生过程中，在有由未角化表皮界定的剥脱区域，会形成标记为I和II的角质细胞层。在剥脱由保留角质层的表皮界定的区域，后者由角质细胞层I和/或II或III组成。光镜和电镜显示角质细胞层有所不同。在不太新鲜的剥脱处，可观察到一种包含纤维蛋白沉积物的均质物质。这种物质在角质层中也经常可见。在不太新鲜的剥脱处和角质层中有大量多形核白细胞。然而，在这些部位，它们仅与含有纤维蛋白沉积物的均质物质同时出现。在真皮乳头和未角化表皮中也可见多形核白细胞，特别是在宏观上“陈旧”的剥脱处。在这些顽固性皮损中观察到的变化被解释为继发性的，并且被认为是门诊患者不断使皮损遭受机械损伤后非特异性反应的表现。它们不被解释为银屑病病情本身的变化。
