Brody I
J Cutan Pathol. 1975;2(4):163-9. doi: 10.1111/j.1600-0560.1975.tb00159.x.
Topical treatment of a number of out-patients with psoriasis vulgaris resulted in reduced induration and diminished thickness of the layer of scales but complete involution was not obtained. A sequential photographic study of the macroscopic appearance of the lesions over a 3-month period of treatment revealed that artificially produced excoriations and a horny layer without scales were prominent features. The view is put forward that the cutaneous reaction to the injury probably elicited by the excoriations, together with an unsatisfactory treatment, may give rise to tissue changes which counteract the effect of topical treatment.
对一些寻常型银屑病门诊患者进行局部治疗后，硬结有所减轻，鳞屑层厚度变薄，但未完全消退。一项对治疗3个月期间皮损宏观外观的连续摄影研究显示，人为造成的擦伤和无鳞屑的角质层是突出特征。有人提出，由擦伤可能引发的皮肤对损伤的反应，再加上治疗效果不理想，可能会导致组织变化，从而抵消局部治疗的效果。
