Keenan E, O'Donnell C, Sinanan K, O'Callaghan E
Cluain Mhuire Family Centre, Blackrock, Co. Dublin, Republic of Ireland.
Acta Psychiatr Scand. 1997 Apr;95(4):272-6. doi: 10.1111/j.1600-0447.1997.tb09631.x.
We examined the relationship between severity of alcohol dependence, subtle neurological impairment, neuropsychological deficits and genetic vulnerability among 36 day hospital attenders who satisfied the DSM-III-R criteria for alcohol dependence. Severity of alcohol dependence was unrelated to the presence of a family history, but was correlated with neurological soft signs and neuropsychological impairment. Neurological soft signs were correlated with neuropsychological impairment on both Trail A and Trail B. Patients with an affected first-degree relative exhibited more neurological soft signs. These data indicate that severity of alcohol dependence is related not only to neuropsychological impairment, but also to subtle neurological deficits which may not be apparent on conventional neurological examination. Patients with a positive family history of alcohol dependence may be particularly susceptible to the neurological sequelae of alcohol dependence, or may have neurological deficits which antedate their alcohol dependence.
我们对36名符合DSM-III-R酒精依赖标准的日间医院就诊者进行了研究，探讨酒精依赖严重程度、轻微神经功能损害、神经心理缺陷与遗传易感性之间的关系。酒精依赖的严重程度与家族史无关，但与神经软体征及神经心理损害相关。神经软体征在A、B两组试验中均与神经心理损害相关。有一级亲属患病的患者表现出更多的神经软体征。这些数据表明，酒精依赖的严重程度不仅与神经心理损害有关，还与常规神经检查中可能不明显的轻微神经缺陷有关。有酒精依赖家族史阳性的患者可能特别容易出现酒精依赖的神经后遗症，或者在酒精依赖之前就存在神经缺陷。
