Neeleman J, Wessely S
Department of Psychological Medicine, King's College Hospital London, UK.
Acta Psychiatr Scand. 1997 Apr;95(4):283-7. doi: 10.1111/j.1600-0447.1997.tb09633.x.
This study compared the number and type of substances taken in deliberate self-poisoning with fatal (n = 127) and non-fatal (n = 521) outcome. The aims were (i) to describe substances typically involved in self-poisoning in England and Wales, (ii) to examine the role of drug "cocktails' and (iii) to examine whether toxic substances are over-represented in cases with fatal outcome. Over-the-counter (OTC) analgesics, minor tranquillizers and antidepressants accounted for about 70% of substances taken, irrespective of outcome. Compared with survivors, cases who died had taken a higher mean number of substances. Among self-poisonings with a single substance, antidepressants and paracetamol-opiate combinations were over-represented in fatal-outcome cases. This report emphasizes the role of OTC analgesics and antidepressants in overdose-related mortality in England and Wales.
本研究比较了蓄意自我中毒且导致死亡（n = 127）和未导致死亡（n = 521）的物质数量及类型。目的是：（i）描述英格兰和威尔士自我中毒中通常涉及的物质；（ii）研究药物“混合物”的作用；（iii）研究有毒物质在致死病例中是否占比过高。无论结果如何，非处方（OTC）镇痛药、轻度镇静剂和抗抑郁药占所摄入物质的约70%。与幸存者相比，死亡病例摄入的物质平均数量更多。在单一物质的自我中毒中，抗抑郁药和对乙酰氨基酚 - 阿片类药物组合在致死病例中占比过高。本报告强调了非处方镇痛药和抗抑郁药在英格兰和威尔士与过量用药相关死亡率中的作用。
