Kotrappa P, Raghunath B, Subramanyam P S, Raikar U R, Sharma S M
J Nucl Med. 1977 Nov;18(11):1082-5.
A compressed-air nebulizer with low holdup and high output was used to nebulize [99mTc] pertechnetate presented in normal saline. Generated droplets were dried in line and led to an inhalation chamber from which the dry aerosol was inhaled using a nose or mouth inhalation unit. The mass median diameter of the particles was 0.8 microns, with an associated geometric standard deviation of 2.0. The deep lung delivery efficiency--defined as the ratio of the activity deposited in the lung area to the activity nebulized--was found to be reproducible and consistent (15-22%) in all the subjects studied. A 3-5 min inhalation of aerosol, nebulized from 20 mCi, was sufficient to provide a lung image of good information density. No noticeable deposit was seen in the trachea or major brochi. The system is inexpensive, stable in performance, adaptable to other solutions or colloids, and is promising for routine use.
使用低滞留量和高输出量的压缩空气雾化器将高锝[99mTc]酸盐雾化于生理盐水中。产生的液滴在线干燥后导入吸入室，通过鼻或口吸入装置从该吸入室吸入干燥的气雾剂。颗粒的质量中值直径为0.8微米，相关的几何标准差为2.0。在所有研究对象中，深肺递送效率（定义为肺部沉积活性与雾化活性之比）具有可重复性且一致（15 - 22%）。从20毫居里雾化的气雾剂进行3 - 5分钟的吸入，足以提供信息密度良好的肺部图像。在气管或主要支气管中未观察到明显的沉积。该系统价格低廉，性能稳定，可适用于其他溶液或胶体，有望用于常规用途。
