Ju S T, Dorf M E
Eur J Immunol. 1979 Jul;9(7):553-60. doi: 10.1002/eji.1830090711.
The immune responses of all inbred strains of mice specific to the synthetic terpolymer poly(LGlu60LAla30LTyr10), referred to as GAT10, are characterized by the presence of anti-GAT antibodies which share a common (CGAT) idiotype. In this report, we describe the ability of the synthetic polymers, LGlu33LAla33LTyr33, LGlu51-LAla34LTyr15 and poly-L(Tyr, Glu)-DLAla--LLys [(T,G)-A--L] to induce antibodies with CGAT idiotypic specificities. All of these polymers contain "GT"-related determinants. Following immunization with these polymers, antisera from responder mice bind the corresponding 125I-labeled antigen and 125I-labeled poly(LGlu50LTyr50) or GAT10. These antisera shared the CGAT idiotype which is associated with the antibody fraction with binding specificity for GAT10. Collectively, the present results indicate that GT-related determinants are required for the induction of the CGAT idiotype. Moreover, since the immune responses to these synthetic polymers are under distinct H-2-linked immune response (Ir) gene control, a mouse strain can be nonresponder to one polymer and responder to another; in this case, only the latter polymer induces CGAT idiotype. Thus, although the immune responses of inbred strains of mice to different polymers are under distinct Ir gene control, the antibody responses can be idiotypically related.
所有对合成三元共聚物聚（L-谷氨酸60%-L-丙氨酸30%-L-酪氨酸10%）（称为GAT10）具有特异性的近交系小鼠的免疫反应，其特征是存在具有共同（CGAT）独特型的抗GAT抗体。在本报告中，我们描述了合成聚合物LGlu33LAla33LTyr33、LGlu51-LAla34LTyr15和聚-L（酪氨酸，谷氨酸）-D-丙氨酸-L-赖氨酸[（T，G）-A-L]诱导具有CGAT独特型特异性抗体的能力。所有这些聚合物都含有“GT”相关决定簇。用这些聚合物免疫后，反应小鼠的抗血清能结合相应的125I标记抗原以及125I标记的聚（L-谷氨酸50%-L-酪氨酸50%）或GAT10。这些抗血清具有与对GAT10具有结合特异性的抗体部分相关的CGAT独特型。总体而言，目前的结果表明，诱导CGAT独特型需要“GT”相关决定簇。此外，由于对这些合成聚合物的免疫反应受不同的H-2连锁免疫反应（Ir）基因控制，一个小鼠品系可能对一种聚合物无反应而对另一种聚合物有反应；在这种情况下，只有后一种聚合物能诱导CGAT独特型。因此，尽管近交系小鼠对不同聚合物的免疫反应受不同的Ir基因控制，但抗体反应在独特型上可能相关。
