Deb S
Department of Psychological Medicine, University of Wales College of Medicine, University Hospital of Wales, Cardiff, UK.
Compr Psychiatry. 1997 May-Jun;38(3):179-84. doi: 10.1016/s0010-440x(97)90072-9.
The controversy regarding the exact nature of the relationship between psychopathology and epilepsy continues. We studied the rate of mental disorder in 150 adults with mental retardation and epilepsy among the residents of a health district of the United Kingdom who lived either in institutions or in the community, and compared them with an age-, sex-, and IQ-matched nonepileptic adult mentally retarded population from the same institution and community. Mental disorder was assessed under three headings, namely severe maladaptive behavior, psychiatric illness according to ICD-9 criteria, and personality disorder. Sixty-five percent of the whole cohort had a diagnosis of mental disorder, and 55% showed severe maladaptive behavior. No significant difference in the rate of mental disorder emerged between the epileptic and nonepileptic groups, although the institutionalized subjects as opposed to the community-based subjects and severely mentally retarded adults compared with the mild to moderately mentally retarded adults showed a significantly higher rate of mental disorder in general and severe maladaptive behavior in particular. We hypothesized that underlying brain damage rather than epilepsy per se is a stronger determinant of psychopathology in the studied patient group.
关于精神病理学与癫痫之间关系的确切性质的争议仍在继续。我们研究了英国一个健康区的居民中150名患有智力障碍和癫痫的成年人的精神障碍发生率，这些居民居住在机构或社区中，并将他们与来自同一机构和社区的年龄、性别和智商匹配的非癫痫成年智力障碍人群进行比较。精神障碍根据三个标题进行评估，即严重适应不良行为、根据国际疾病分类第九版（ICD - 9）标准的精神疾病和人格障碍。整个队列中有65%被诊断患有精神障碍，55%表现出严重适应不良行为。癫痫组和非癫痫组之间精神障碍发生率没有显著差异，尽管与社区居民相比，机构化的受试者以及与轻度至中度智力障碍成年人相比的严重智力障碍成年人总体上精神障碍发生率显著更高，尤其是严重适应不良行为。我们假设在所研究的患者群体中，潜在的脑损伤而非癫痫本身是精神病理学的更强决定因素。
