Kanno H
Clinical Laboratory Medicine, Medical School of Chiba University.
Nihon Rinsho. 1997 May;55(5):1191-9.
As for the methods for dilution antimicrobial susceptibility tests, the results are expressed quantitatively as minimum inhibitory concentration (MIC). MICs are useful index not only for the choice of antibiotics to the treatment of infectious diseases but the exact detection of resistant strains. Recently, the study for the mechanism of the bacterial resistance to antibiotics were made remarkable progress, the important point of MICs in the combination of species and antibiotics were become clear. To improve the quality of the susceptibility tests, it is necessary to come into wide use of the dilution antimicrobial susceptibility tests instead of the disk susceptibility tests which are popular in JAPAN.
至于稀释抗菌药敏试验的方法,结果以最低抑菌浓度(MIC)定量表示。MIC不仅是选择治疗传染病抗生素的有用指标,也是准确检测耐药菌株的指标。近年来,关于细菌抗生素耐药机制的研究取得了显著进展,MIC在菌种与抗生素组合中的重要性已变得清晰。为提高药敏试验的质量,有必要广泛采用稀释抗菌药敏试验,而非在日本流行的纸片药敏试验。