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免疫增强型肠内营养制剂:对重症患者有益吗?

Immune-enhancing enteral formulas: are they beneficial in critically ill patients?

作者信息

Barton R G

机构信息

Department of Surgery, University of Utah, School of Medicine, Salt Lake City 84132, USA.

出版信息

Nutr Clin Pract. 1997 Apr;12(2):51-62. doi: 10.1177/011542659701200251.

DOI:10.1177/011542659701200251
PMID:9155402
Abstract

Over the last decade there has been considerable interest in the use of specific nutrients to alter the metabolic response to injury and infection, to improve immune function, and to prevent or reverse the severe catabolism and wasting of the lean body mass that accompanies critical illness. In this review, representative animal studies and, when available, human studies examining the potential benefits of these individual nutrients are summarized. The overview of basic investigations is by no means all-inclusive, and the emphasis of this manuscript is a review of the currently available clinical trials examining the potential benefits of combinations of these individual immunity-enhancing nutrients in human patients.

摘要

在过去十年中,人们对使用特定营养素来改变机体对损伤和感染的代谢反应、改善免疫功能以及预防或逆转危重病时伴随的严重分解代谢和瘦体重消耗产生了浓厚兴趣。在这篇综述中,总结了具有代表性的动物研究以及(如有)考察这些单一营养素潜在益处的人体研究。基础研究的概述绝非全面涵盖所有内容,本手稿的重点是综述目前可用的临床试验,这些试验考察了这些单一免疫增强营养素组合对人类患者的潜在益处。

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Immune-enhancing enteral formulas: are they beneficial in critically ill patients?免疫增强型肠内营养制剂:对重症患者有益吗?
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引用本文的文献

1
Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: a randomized clinical trial.在无严重脓毒症的危重症患者中,早期肠内免疫营养与肠外营养的比较:一项随机临床试验。
Intensive Care Med. 2006 Aug;32(8):1191-8. doi: 10.1007/s00134-006-0238-y. Epub 2006 Jun 21.
2
Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial.严重脓毒症患者的早期肠内免疫营养:一项随机多中心临床试验的中期分析结果
Intensive Care Med. 2003 May;29(5):834-40. doi: 10.1007/s00134-003-1711-5. Epub 2003 Apr 9.