Chakraborti P R, Chakrabarti K B, Doughty D, Plowman P N
Department of Radiotherapy and Clinical Oncology, St. Bartholomew's Hospital, London, UK.
Br J Neurosurg. 1997 Apr;11(2):110-5. doi: 10.1080/02688699746447.
Our initial experience in the treatment of haemangioblastoma using conventional external beam radiotherapy and stereotactic radiotherapy (radiosurgery), by the linear accelerator method, is reported. Six haemangioblastomas in five patients were treated with a mean follow-up of 40 months (range 14-60). Five haemangioblastomas in four patients were treated with stereotactic radiotherapy, where four showed complete radiological response and the fifth was static. Neurological symptoms and signs improved in those patients. The sixth haemangioblastoma was situated close to the pituitary and optic chiasm, and was treated with conventionally fractionated external beam radiotherapy. The lesion showed partial response. No complications were noted in this patient group. This series complements and extends the relatively sparse published literature demonstrating that radiotherapy is an effective option for treating haemangioblastomas. Radiosurgery often lends itself particularly well to these discrete lesions allowing highly focused treatment. For patients with multiple and metachronous cerebellar haemangioblastomas as part of the von Hipple-Lindau syndrome, the data support a policy of conventionally fractionated external beam radiotherapy to the whole cerebellum of 50-55 Gy followed, after a period of time, by radiosurgery to persisting lesions (patients 3 and 4).
本文报告了我们使用传统外照射放疗和立体定向放疗（放射外科），即线性加速器方法治疗血管母细胞瘤的初步经验。对5例患者的6个血管母细胞瘤进行了治疗，平均随访40个月（范围14 - 60个月）。对4例患者的5个血管母细胞瘤进行了立体定向放疗，其中4个显示出完全的放射学反应，第5个病情稳定。这些患者的神经症状和体征有所改善。第6个血管母细胞瘤位于垂体和视交叉附近，采用传统分次外照射放疗，病变显示部分反应。该患者组未观察到并发症。本系列补充并扩展了相对较少的已发表文献，表明放疗是治疗血管母细胞瘤的有效选择。放射外科通常特别适用于这些离散病变，能够进行高度聚焦的治疗。对于患有多个和异时性小脑血管母细胞瘤作为冯·希佩尔 - 林道综合征一部分的患者，数据支持对整个小脑进行50 - 55 Gy的传统分次外照射放疗，一段时间后，对持续存在的病变进行放射外科治疗（患者3和4）。
