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[溶解于不同输液溶液中的链激酶制剂Awelysin的免疫浓度测定以评估其稳定性]

[Immunological concentration determinations of the streptokinase preparation Awelysin dissolved in various infusion solutions for its stability evaluation].

作者信息

Hindersin P, Vogel G

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1979;106(2):254-9.

PMID:91562
Abstract

By means of the electro-immuno-assay according to Laurell the decrease of concentration was determined for the streptokinase preparation Awelysin dissolved in various infusion media at 20 degrees C. The stability behaviour of a streptokinase solution of 1.000 IE/ml showed a significant decrease of concentration after 24 hours (alpha less than 5%) as compared with the initial concentration. However, in comparison no significant differences as to the streptokinase stability could be found by using different infusion solutions. At 20 degrees C the decrease of streptokinase concentration may be neglected up to 24 hours in an infusion solution of streptokinase previously prepared.

摘要

采用劳雷尔(Laurell)的电免疫分析法,测定了20℃下溶解于各种输液介质中的链激酶制剂Awelysin的浓度降低情况。1.000 IE/ml链激酶溶液的稳定性表现为,与初始浓度相比,24小时后浓度显著降低(α<5%)。然而,相比之下,使用不同的输液溶液时,在链激酶稳定性方面未发现显著差异。在20℃下,对于预先制备的链激酶输液溶液,在24小时内链激酶浓度的降低可忽略不计。

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