Klopman G, Tu M, Talafous J
Chemistry Department, Case Western Reserve University, Cleveland, Ohio, USA.
J Chem Inf Comput Sci. 1997 Mar-Apr;37(2):329-34. doi: 10.1021/ci9601123.
META is a knowledge-based expert system that simulates the biotransformation of xenobiotics. It operates with the help of a dictionary (knowledge base) to seek target fragments in a compound and transform them to products. Here, a genetic algorithm is introduced to help build the knowledge base and optimize the performance of the methodology.
META是一个基于知识的专家系统，用于模拟外源性物质的生物转化。它借助一个词典（知识库）来寻找化合物中的目标片段并将其转化为产物。在此，引入了一种遗传算法来帮助构建知识库并优化该方法的性能。
