Bakos N, Szemere P
Hetényi Géza Kórház, Szolnok, Bõrgyógyászati Osztálya.
Orv Hetil. 1997 Mar 9;138(10):587-92.
The atopic dermatitis is a multifactorial inheritable disease, in which pathogenesis in addition to environmental factors (climate, allergens, clothing) genetically determined multiplex metabolic differences (arachidonic acids, essential fatty acids) and immunologic alterations play an important role. Within immunologic findings the disturbances of balance in Th1 and Th2 subclasses, the increased degranulation activity of mast cells and the increased antigen presentation activity of Langerhans cells can be stressed. The clinical immunological alterations shown in the diseases, the increased production of IgE and so the type I. allergic reactions (urticaria, gastrointestinal manifestation of food allergy, allergic rhinitis, asthma bronchiale), the difference of cellular immunity of the skin can be explained by the above mentioned main immunological changes. In understanding of immunological origin of atopic dermatitis the IgE receptors expressed on the surface of Langerhans cells (connecting the immediate and delayed type of immune response) mean significant help.
特应性皮炎是一种多因素遗传性疾病，其发病机制中，除环境因素（气候、过敏原、衣物）外，基因决定的多种代谢差异（花生四烯酸、必需脂肪酸）和免疫改变也起重要作用。在免疫学发现中，Th1和Th2亚类平衡的紊乱、肥大细胞脱颗粒活性增加以及朗格汉斯细胞抗原呈递活性增加值得关注。该疾病中出现的临床免疫学改变，如IgE产生增加以及由此导致的I型过敏反应（荨麻疹、食物过敏的胃肠道表现、过敏性鼻炎、支气管哮喘）、皮肤细胞免疫的差异，都可以用上述主要免疫学变化来解释。在理解特应性皮炎的免疫起源方面，朗格汉斯细胞表面表达的IgE受体（连接即时和迟发型免疫反应）具有重要帮助。
