哌啶衍生物：3-取代-4-苯基哌啶系列潜在镇痛药的合成
Piperidine derivatives: synthesis of potential analgesics in 3-substituted 4-phenylpiperidine series.
作者信息
Abbas R, Willette R E, Edwards J M
出版信息
J Pharm Sci. 1977 Nov;66(11):1583-5. doi: 10.1002/jps.2600661121.
PMID:915735
Abstract
The syntheses of 1-methyl-3-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-piperidinol and 1-methyl-3(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propanoyloxypiperidine are described. Preliminary pharmacological testing showed these compounds to be weakly active in the writhing test.
摘要
描述了1-甲基-3-(3-羟基-3-苯基丙基)-4-苯基-4-哌啶醇和1-甲基-3-(3-羟基-3-苯基丙基)-4-苯基-4-丙酰氧基哌啶的合成。初步药理测试表明这些化合物在扭体试验中活性较弱。
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