吲哚美辛与溶酶体及蛋白质的相互作用。
Interactions of indomethacin with lysosomes and proteins.
作者信息
Lewis D A, Krygier H E
出版信息
J Pharm Sci. 1977 Nov;66(11):1651-2. doi: 10.1002/jps.2600661144.
PMID:915754
Abstract
The stabilizing action of indomethacin on lysosomes and protein in vivtro was studied. The magnitude of the stabilizing action on lysosomes was greater than that of aspirin or oxyphenbutazone, similar to that of phenylbutazone, but less than that of prednisolone. The stabilizing action of indomethacin on lysosomes possibly may contribute to its anti-inflammatory properties.
摘要
研究了吲哚美辛在体外对溶酶体和蛋白质的稳定作用。其对溶酶体的稳定作用强度大于阿司匹林或羟苯丁宗，与保泰松相似，但小于泼尼松龙。吲哚美辛对溶酶体的稳定作用可能有助于其抗炎特性。
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