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[类线粒体DNA序列与哺乳动物核基因组和线粒体基因组功能的协调]

[MtDNA-like sequences and the coordination of the functioning of mammalian nuclear and mitochondrial genomes].

作者信息

Maliarchuk B A

出版信息

Tsitol Genet. 1997 Mar-Apr;31(2):53-61.

PMID:9157643
Abstract

Mitochondrial DNA-like sequences in the nuclear genome of mammals are classified in two types: ontogenetic and evolutionary. Mechanisms of the transfer of DNA from mitochondria into nucleus and transformation of the ontogenetic mtDNA-like sequences to evolutionary ones are discussed. The origin of short sequences of DNA common to nuclear and mitochondrial genome and the role of these sequences in the coordination of gene expression have received much attention.

摘要

哺乳动物核基因组中的线粒体DNA样序列可分为两类:个体发育型和进化型。本文讨论了DNA从线粒体转移到细胞核的机制,以及个体发育型线粒体DNA样序列向进化型序列的转变。核基因组和线粒体基因组共有的短DNA序列的起源,以及这些序列在基因表达协调中的作用,已受到广泛关注。

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