Patronek G J, Waters D J, Glickman L T
Department of Veterinary Pathobiology, Purdue University, USA.
J Gerontol A Biol Sci Med Sci. 1997 May;52(3):B171-8. doi: 10.1093/gerona/52a.3.b171.
The effect of breed and body weight on longevity in the pet dog was analyzed, and a method was developed to standardize the chronological age of dogs in terms of physiological time, using human year equivalents. Mortality data from 23,535 pet dogs were obtained from a computerized data base of North American veterinary teaching hospitals, and the median age at death was determined for pure and mixed breed dogs of different body weight. Body size in the dog was inversely related to longevity. Within each body weight category, the median age at death was lower for pure breed dogs compared with mixed breed dogs. The difference between the standardized physiological ages of mixed breed dogs of the same chronological age in the smallest and largest body weight categories varied from 8 to > 15 years, and between large and small pure breed dogs, the disparity was even greater. Laboratory research to explore the biological basis for these breed and body weight specific differences in life span among dogs may provide additional clues to genetic factors influencing senescence.
分析了品种和体重对宠物狗寿命的影响，并开发了一种方法，使用相当于人类年龄的方式，根据生理时间对狗的实际年龄进行标准化。从北美兽医教学医院的计算机数据库中获取了23535只宠物狗的死亡率数据，并确定了不同体重的纯种和混种狗的死亡年龄中位数。狗的体型与寿命呈负相关。在每个体重类别中，纯种狗的死亡年龄中位数低于混种狗。最小和最大体重类别的相同实际年龄的混种狗的标准化生理年龄差异从8岁到超过15岁不等，而大型和小型纯种狗之间的差距更大。探索狗寿命中这些品种和体重特异性差异的生物学基础的实验室研究可能会为影响衰老的遗传因素提供更多线索。
