Nasmyth K, Jansen R P
Research Institute of Molecular Pathology, Dr Bohr-Gasse 7, A-1030, Vienna, Austria.
Curr Opin Cell Biol. 1997 Jun;9(3):396-400. doi: 10.1016/s0955-0674(97)80013-0.
Asymmetric distribution of cytoplasmic proteins and messenger RNAs has been implicated in several instances of cell differentiation. Microtubules have been suggested to direct mRNA localization in Drosophila and Xenopus oocytes but motor proteins that might transport mRNAs have not yet been identified. Recent data imply that in Drosophila, Caenorhabditis elegans and budding yeast, proteins of the actin cytoskeleton, including unconventional myosins, play active roles in the segregation of differentiation factors and mRNAs.
细胞质蛋白和信使核糖核酸的不对称分布与细胞分化的多种情况有关。在果蝇和非洲爪蟾卵母细胞中，微管被认为可指导信使核糖核酸的定位，但尚未鉴定出可能转运信使核糖核酸的运动蛋白。最近的数据表明，在果蝇、秀丽隐杆线虫和芽殖酵母中，包括非常规肌球蛋白在内的肌动蛋白细胞骨架蛋白在分化因子和信使核糖核酸的分离中发挥着积极作用。
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