Tollervey D, Kiss T
Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK.
Curr Opin Cell Biol. 1997 Jun;9(3):337-42. doi: 10.1016/s0955-0674(97)80005-1.
Eukaryotic cells contain an extraordinarily complex population of small nucleolar RNAs (snoRNAs). During its brief lifetime, each human pre-rRNA molecule will transiently associate with approximately 150 different snoRNA species. In the past year our understanding of snoRNAs has been clarified by the recognition that the snoRNA population can be divided into a small number of groups which are structurally and functionally distinct. The two largest groups of snoRNAs direct the site-specific modification of the pre-rRNA at positions of 2'-O-methylation and pseudouridine formatio. Other groups of snoRNAs function in pre-rRNA cleavage and in the formation of the correct structure of the pre-rRNA.
真核细胞含有极其复杂的小分子核仁RNA（snoRNA）群体。在其短暂的生命周期中，每个人类前体核糖体RNA（pre-rRNA）分子将短暂地与大约150种不同的snoRNA种类相关联。在过去的一年里，我们对snoRNA的理解因认识到snoRNA群体可分为少数几个在结构和功能上不同的组而变得清晰。最大的两组snoRNA指导前体rRNA在2'-O-甲基化和假尿苷形成位置的位点特异性修饰。其他组的snoRNA在前体rRNA切割和前体rRNA正确结构的形成中发挥作用。
