Chintala S K, Rao J K
Department of Neurosurgery, Box 064, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Front Biosci. 1996 Nov 1;1:d324-39. doi: 10.2741/a135.
The invasion of glioma into normal brain tissue is a major challenge to clinical intervention because these tumors often highly infiltrate the surrounding brain tissue. Total surgical resection of gliomas is impossible, and recurrence of tumor growth is a common phenomenon; patients have a mean survival time of 8-12 months. Although in recent years substantial progress has been made toward understanding the invasive behavior of gliomas in vitro and in vivo, the factors responsible for the extensive infiltration are still poorly documented. This review focuses on recent research concerning the invasion of gliomas, as well as the extracellular matrix components, and the proteolytic enzymes involved. A better understanding of cell-matrix interactions will help in developing therapeutic strategies to decrease the invasion of gliomas.
胶质瘤侵袭正常脑组织是临床干预面临的一项重大挑战，因为这些肿瘤常常高度浸润周围脑组织。胶质瘤的完全手术切除是不可能的，肿瘤生长复发是常见现象；患者的平均生存时间为8至12个月。尽管近年来在了解胶质瘤在体外和体内的侵袭行为方面取得了重大进展，但导致广泛浸润的因素仍鲜有记载。本综述重点关注有关胶质瘤侵袭以及细胞外基质成分和相关蛋白水解酶的最新研究。更好地理解细胞与基质的相互作用将有助于制定减少胶质瘤侵袭的治疗策略。
